Effect of Cholecystokinin-Octapeptide on Lower Esophageal Sphincter
نویسندگان
چکیده
منابع مشابه
Interaction of pentagastrin and the octapeptide of cholecystokinin on the human lower oesophageal sphincter.
The intravenous infusion of the octapeptide of cholecystokinin inhibited the response of the lower oesophageal sphincter to graded doses of pentagastrin in normal men. The possibility that the effects of these peptides on the lower oesophageal sphincter are only pharmacological and not physiological is discussed.
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We studied the effect of cholecystokinin (CCK) and the octapeptide of cholecystokinin (OP-CCK) on the feline gallbladder and sphinecter of Oddi. Both CCK caused a dose-dependent gallbladder contraction and sphincter of Oddi relaxation. The half-maximal responses of the sphincter of Oddi were 6 ng/kg for OP-CCK and 0.15 Ivy-dog U/kg for CCK, which were lower than those of the gallbladder with 28...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1977
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)32272-3